Combined Modality Treatment Outcomes for Head and Neck Cancer

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Combined-Modality Therapy for Head and Neck Cancer

Chemotherapy has often been combined with radiotherapy and/or surgery in the treatment of patients with advanced head and neck cancer in an attempt to improve locoregional control, decrease distant metastasis, and increase survival. Recently, induction chemotherapy has been used in the selection of patients with advanced resectable carcinoma of the larynx and hypopharynx for organ preservation....

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Combined-modality therapy for locoregionally advanced head and neck cancer.

Traditionally, treatment for locally advanced resectable head and neck cancer has been surgical resection followed by postoperative radiation. In unresectable patients, primary radiation has been the mainstay of treatment. In an attempt to improve local control and survival, chemotherapy has been investigated as an adjunct to locoregional treatment. Induction or adjuvant chemotherapy in combina...

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Combined modality therapy for advanced head and neck cancer.

Seventy-five patients with stage III and IV squamous cell cancer of the head and neck, previously untreated, had two courses of chemotherapy with cis-platinum, Oncovin and bleomycin, followed by radical surgery, radiotherapy or both. Response to chemotherapy (complete and partial) was high (80 percent). In 36 patients radical surgery became possible. The overall survival improved statistically ...

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Combined-Modality Therapy of Head and Neck Cancer

Head and neck cancer occurs at an incidence of approximately 40,000 cases annually in the United States.[1] Approximately one-third of patients present with early-stage disease, which is usually cured with single-modality surgery or radiation therapy.[2] The great majority of the remaining patients present with locoregionally advanced disease, ie, large primaries (T3, T4) and/or involvement of ...

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Combined modality therapy of head and neck cancer.

The treatment of head and neck cancer has traditionally consisted of surgery with postoperative radiation therapy. Chemotherapy has been reserved for palliation. In recent years, induction chemotherapy has been shown to allow for larynx preservation in patients with laryngeal or hypopharyngeal cancer. Concomitant chemoradiotherapy has been shown to provide a statistically significant survival b...

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ژورنال

عنوان ژورنال: JAMA Otolaryngology–Head & Neck Surgery

سال: 2013

ISSN: 2168-6181

DOI: 10.1001/jamaoto.2013.4539